品牌：PEPROTECH
货号：AF-214-14
名称：Animal-Free Recombinant Murine IL-4
规格：1mg
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Murine IL-4 is a 13.5 kDa globular protein containing 121 amino acid residues.
Source:E.coli
Synonyms:BCGF, BCDF, B cell stimulating factor (BSF-1)
AA Sequence:MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S
Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:The ED50 was determined by the dose-dependent stimulation of the proliferation of murine HT-2 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
This product has been tested against the WHO standard. International Unit information can be found here.
Calculated Molecular Weight:13.5 kDa
Accession Number:P07750
Gene ID:16189
