品牌:PEPROTECH
货号:AF-200-13
名称:Animal-Free Recombinant Human IL-13
规格:2µg 10µg 50µg 100µg 250µg 500µg 1mg
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 are cross-species reactive. Recombinant Human IL-13 is a 12.6 kDa protein consisting of 115 amino acid residues.
Manufactured using all Animal-Free reagents.
Source:E.coli
Synonyms:NC30 (Human), P600 (Murine)
AA Sequence:MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGRFN
Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥1 x 106 units/mg.
This product has been tested against the WHO standard. International Unit information can be found here.
Calculated Molecular Weight:12.6 kDa
Accession Number:P35225
Gene ID:3596
crossreactivity:
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